Charlotta Böiers Group
Acute Lymphoblastic Leukemia (ALL) is one of the most common cancers in children. While this type of malignancy is found in both children and adults, childhood ALL differs from the disease in adults with higher incidence, better prognosis but also a specific mutational spectrum. These facts suggest differences in the underlying biology and in the initiation of the disease between adults and children. Many of the initiation mutations in childhood leukemia have been shown to occur already during fetal life. The targeted cells form a pre-leukemic clone, pre-disposed to develop leukemia when encountering additional mutations. Differences in fetal and adult lineage hierarchies and target cells could explain part of the differences seen in the disease in children and adults. How the leukemia process initiates is poorly understood and childhood leukemia offers a unique possibility to study this since many of the initiation mutations are known. The main focus of my laboratory is to understand how the leukemia starts: the origin of the pre-leukemic clone and the molecular pathways which regulate the initiation of leukemia.
If we can understand the initiation of leukemia and how the pre-leukemic clone is formed, we can design better treatments with less toxicity and better efficacy, and in the future improve prognosis for these children.
- A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1. Böiers C*, Richardson SE*, Laycock E, Zriwil A, Turati VA, Brown J, Wray JP, Wang D, James C, Herrero J, Sitnicka E, Karlsson S, Smith AJH, Jacobsen SE & Enver T. *equal contribution. Developmental Cell, 2018. Feb 5;44(3): 362-377.
- Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition. Guibentif C, Rönn R, Böiers C, Lang S, Saxena S, Soneji S, Enver T, Karlsson G*& Woods NB*. Cell Reports, 2017, April 4; 19(1): 10-19.
- Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors. Luis TC, Luc S, Mizukami T, Boukarabila H, Thongjuea S, Woll P, Azzoni E, Giustacchini A, Lutteropp M, Bouriez-Jones T, Vaidya H, Mead A, Atkinson D, Böiers C, Carrelha J, Macaulay I, Patient R, Geissmann F, Nerlov C, Sandberg R, de Bruijn M, Blackburn C, Godin I & Jacobsen SE. Nature Immunology, 2016, Dec 1;17(12): 1424-1435.
- Macrophage colony-stimulating factor receptor marks and regulates a fetal myeloid-primed B-cell progenitor in mice. Zriwil A, Böiers C, Wittmann L, Green JC, Woll PS, Jacobsen SE & Sitnicka E. Blood, 2016, July 14; 128(2):217-226.
- Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells. Böiers C, Carrelha J, Lutteropp M, Luc S, Green JC, Azzoni E, Woll PS, Mead AJ, Hultquist A, Swiers G, Perdiguero EG, Macaulay IC, Melchiori L, Luis TC, Kharazi S, Bouriez-Jones T, Deng Q, Pontén A, Atkinson D, Jensen CT, Sitnicka E, Geissmann F, Godin I, Sandberg R, de Bruijn MF & Jacobsen SE. Cell Stem Cell, 2013 Nov 7;13(5):535-48.
Phone: +46 (0)46 222 06 40
Mobile: +46 (0)70 943 68 12
Email: charlotta [dot] boiers [at] med [dot] lu [dot] se
Ariana Seira Calderón Moreno
ariana_seira [dot] calderon_moreno [at] med [dot] lu [dot] se
shabnam [dot] kharazi [at] med [dot] lu [dot] se
PhD, Research Engineer
roshanak [dot] ghazanfari [at] med [dot] lu [dot] se
Division of Molecular Hematology
Lund Stem Cell Center, Lund University
SE-221 84 Lund
Room: BMC, B1227b