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Joan Yuan Group

Developmental Immunology

Joan Yuan Group

Our research


The dogma of hematopoiesis states that bone marrow hematopoietic stem cells (HSCs) produce a life time supply of blood and immune cells with limited lifespans and require continuous replenishment. However, antibody producing B cells in unperturbed adult mice are ontogenically distinct with a significant portion being generated within the first weeks of life and self-sustaining throughout adulthood. Our previous work has demonstrated a critical role for the Lin28b RNA binding protein in mediating a juvenile-to-adult switch in B cell output at the level of hematopoietic stem and progenitor cells (Yuan et al. Science, 2012, Kristiansen et al. Immunity, 2016). Our most recent paper identifies the central tolerance checkpoint as a major target of Lin28b regulation, demonstrating that Lin28b augments the positive selection of self-reactive B cells during a restricted developmental window in the first weeks of life (Vanhee et al. Science Immunology, 2019).


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Currently, we are focused on pursuing the molecular, cellular and environmental determinants that control the timing and outcome of this developmental switch as well as its impact on host immunity and disease. By combining several lineage tracing approaches that track immune cells of distinct ontogeny across developmental time, with antigen receptor repertoire analyses, well-established immunization strategies, and cancer models, our work aims to address: how nature and nurture in the neonatal period shapes the formation of a complex and balanced immune system with important implications in life-long health and the origin of B cell cancers.

Selected publications

  1. Lin28b controls a neonatal to adult switch in B cell positive selection. Vanhee S, Åkerstrand H, Kristiansen TA, Datta S, Montano G, Vergani S, Lang S, Ungerbäck J, Doyle A, Olsson K, Beneventi G, Jensen CT, Bellodi C, Soneji S, Sigvardsson M, Jaensson Gyllenbäck E, Yuan J. Sci. Immunol. 2019 Sept; 4:39
     
  2. The influence of developmental timing on B cell diversity. Kristiansen TA, Vanhee S, Yuan J. Current Opinions in Immunology. 2018 Apr;51:7-13.
     
  3. PTIP chromatin regulator controls development and activation of B cell subsets to license humoral immunity in mice. Su D, Vanhee S, Soria R, Gyllenbäck EJ, Starnes LM, Højfeldt MK, Pedersen GK, Yuan J, Daniel JA. PNAS. 2017 Oct 31;114
     
  4. Cellular barcoding links B-1a B cell potential to a reversible fetal hematopoietic stem cell state at the single cell level. Kristiansen TA, Jaensson Gyllenbäck E, Zriwil A, Björklund T, Daniel JA, Sitnicka E, Soneji S, Bryder D, Yuan J. Immunity. 2016 Aug. 45;346-357
     
  5. Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Yuan J, Nguyen CK, Liu X, Kanellopoulou C, Muljo SA. Science. 2012 Mar 9;335(6073):1195-200.
Page Manager:

Joan Yuan

Joan Yuan

Associate Professor

Phone: +46 (0)46 222 04 30
Mobile: +46 (0)72 586 88 02
E-mail: joan [dot] yuan [at] med [dot] lu [dot] se

Lund University Research Portal

Group Members

Sneh Lata Gupta
Postdoctoral fellow
sneh_lata [dot] gupta [at] med [dot] lu [dot] se

Stefano Vergani
Postdoctoral fellow
stefano [dot] vergani [at] med [dot] lu [dot] se

Trine Kristiansen
Postdoctoral fellow
trine [dot] kristiansen [at] med [dot] lu [dot] se

Hugo Kerstrand
Doctoral student
hugo [dot] akerstrand [at] med [dot] lu [dot] se

Karin Olsson
Laboratory Engineer
karin [dot] olsson [at] med [dot] lu [dot] se

Alexander Doyle
Research Engineer
alexander [dot] doyle [at] med [dot] lu [dot] se

Giorgia Montano
Research Engineer
giorgia [dot] montano [at] med [dot] lu [dot] se

Niklas Krausse
Doctoral student
niklas [dot] krausse [dot] 0471 [at] med [dot] lu [dot] se

Selene Sodini
Project Assistant
selene [dot] sodini [at] med [dot] lu [dot] se

Elena Boldrin
Postdoctoral Fellow
elena [dot] boldrin [at] med [dot] lu [dot] se

Visiting address

Division of Molecular Hematology
Lund Stem Cell Center, Lund University
Klinikgatan 26
SE-221 84 Lund
SWEDEN

Room: BMC, B1215b

Molecular Hematology
Department of Laboratory Medicine, Faculty of Medicine
Lund University
Box 117
SE-221 00 LUND
SWEDEN

E-mail & phone: info [at] med [dot] lu [dot] se  +46 (0)46 222 0000