Translational Molecular Hematology
Whereas clinical hematology is the branch of medicine concerned with the study, diagnosis, treatment, and prevention of blood disorders, molecular hematology can be defined as the study of hematopoiesis from a molecular and genetic perspective. For several decades, the hematopoietic system has been the foremost biological model when investigating human malignant disease. Seminal findings in both the laboratory and clinical setting have resulted in a staggering increase of survival in pediatric leukemia, as well as a plethora of new therapeutic tools, making hematology a model of modern translational research.
The main goal of our laboratory is to use the current understanding of hematopoiesis and put this in a clinical context, to be able to employ this knowledge in identifying new biomarkers and potential therapeutic targets for primarily pediatric blood disorders. In addition, another goal is to take novel clinical discoveries, e.g. mutations or epigenetic findings linked to specific hematopoietic pathophenotypes, and use them as a foundation for basic research projects regarding hematopoietic stem and progenitor cell regulation and function.