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Stefan Scheding Group

Bone Marrow (Stromal) Stem Cells and Cellular Therapies

Our research


Human bone marrow (BM) contains the hematopoietic stem cells (HSC) as well as a rare population of non-hematopoietic bone marrow stromal stem cells (BMSC). The HSCs are responsible for the life-long production of the different blood cells, whereas BMSCs generate skeletal tissues and give rise to the hematopoietic microenvironment (HME)

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One major focus of our research is therefore to study bone marrow hematopoietic and stromal stem cells and their crosstalk in healthy and diseased bone marrow, aiming to develop therapies to repair or eliminate and replace dysfunctional HSCs and BMSCs, thus leading to improved therapies for patients with hematological malignancies.

Malignant HSC can be replaced by transplantation of healthy donor stem cells (so-called hematopoietic stem cell transplantation, HSCT), which is the only curative treatment for patients with high-risk hematological malignancies. However, HSCT is a potentially dangerous procedure with severe side-effects which cause a considerable treatment-related morbidity and mortality.

Therefore, another major line of research in our lab focuses on the development of novel novel and improved stem cell collection and separation technologies and transplantation biomarker assays based on acoustic sorting (acoustophoresis).

Finally, we are actively involved in the development of a GMP infrastructure that will allow to translate the therapies developed in StemTherapy and other programs into clinical advanced medicinal products (ATMP). Here, we are represented in key positions in the National Tissue Project (Vävnadsrådet) and the National Center for Advanced Medical Products, CAMP.

Selected publications

 

  1. Li H, Lim HC, Zacharaki D, Xian X, Kenswill KJG, Meyer S, Raaijmakers MHG, Woods NB, Hansson J, Scheding S. Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells. Haematologica (2020) May;105(5):1206-1215
     
  2. Zacharaki D, Li H, Scheding S. Human Primary Bone Marrow Stromal Cells Ð Basic Biology and Isolation Strategies. In: Zaidi, M. (ed) Encyclopedia of Bone Biology, Elsevier (2020), vol. 1, 26-34
     
  3. Olm F, Lim HC, Schallmoser K, Strunk D, Laurell T, Scheding S. Acoustophoresis enables the label-free separation of functionally different subsets of cultured bone marrow stromal cells. Cytometry Part A (2020)
     
  4. Li H, Ghazanfari R, Zacharaki D, Ditzel N, Isern J, Ekblom M, Mendez-Ferrer S, Kassem M, Scheding S. Low/Negative Expression of PDGFR-? Identifies the Candidate Primary Mesenchymal Stem Cells in Adult Human Bone Marrow. Stem Cell Reports (Cell Press) 2014 Dec 9;3(6):965-74
     
  5. Tormin A, Li O, Brune JC, Walsh S, Schütz B, Ehinger M, Ditzel N, Kassem M, Scheding, S. CD146 Expression on Primary Non-Hematopoietic Bone Marrow Stem Cells is Correlated with in situ Localization. Blood (2011) 117(19):5067-5077
Page Manager:

Stefan Scheding

Stefan Scheding

Professor, senior consultant in hematology

Phone: +46 (0)46 222 33 31
Mobile: +46 (0)70 454 90 90
E-mail: stefan [dot] scheding [at] med [dot] lu [dot] se

Lund University Research Portal

Group members

Hongzhe Li
PhD, Researcher
hongzhe [dot] li [at] med [dot] lu [dot] se

Sandro Bräunig
PhD student
sandro [dot] braunig [at] med [dot] lu [dot] se

Marie Magnusson
Laboratory technician
marie [dot] magnusson [at] med [dot] lu [dot] se

Hooi-Ching Lim
PhD, Researcher
hooi_ching [dot] lim [at] med [dot] lu [dot] se


Co-supervision:

Mans Kadefors
PhD student
mans [dot] kadefors [at] med [dot] lu [dot] se

Franziska Olm
Postdoc
franziska [dot] olm [at] med [dot] lu [dot] se

Visiting address

Division of Molecular Hematology
Lund Stem Cell Center, Lund University
Klinikgatan 26
SE-221 84 Lund
SWEDEN

Room: BMC B1205c (office), BMC B1209a (lab)
 

Molecular Hematology
Department of Laboratory Medicine, Faculty of Medicine
Lund University
Box 117
SE-221 00 LUND
SWEDEN

E-mail & phone: info [at] med [dot] lu [dot] se  +46 (0)46 222 0000